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This system involved the administration of anabolic steroids on rats, either orally or by injection (depending on the anabolic steroid being assessed)into the peritoneal cavity (Pasadena et al., 1974).

The method of administration involved administering the anabolic steroids using an intravenous needle in a series of seven subcutaneous injections.

Two doses of the test steroids were administered per injection, and a total of eight injections were obtained over 3.25 h (Bennett et al., 1979).

To assess the anabolic capacity of the test steroid in relation to a number of different anabolic androgenic steroids (androgenic steroid and its metabolite) was measured by measurement of testosterone and growth hormone levels.

To determine whether the effects of the anabolic steroids were permanent, the rats were subjected to a number of recovery tests and were sacrificed 3 weeks after the last injection, when the levels of the anabolic steroids were in the normal range, and the serum testosterone levels were in their normal range.

The testosterone levels could be measured using a blood gas analyzer (Boyle et al., 1975).

Tables of the tests on animals are shown in the table below.

TABLE II.

Testosterone and Growth Hormone Values for the Anabolic Steroids Tested Assume anabolic steroid of the specified mass (M) and dosage (mg). Testosterone (T) Testosterone (T.W.) Growth Hormone (GH) Testosterone (T.W.) GH (T) Testosterone (M) W = Testosterone; T = Testosterone (M).

TABLE III.

Testosterone and Testosterone-Estradiol (E2): Analyses of the Ingestion of Estradiol and Growth Hormone Ingested by Animals.

Subjects M W E2 GH GH (M) W E2 GH (M) T (M) T [M] P 1 — — — — — 1,2 3 0.4 0.4 0.4 9 6 0.8 0.8 0.8 18 9 — 0.04 0 0.18 5 — 0.6 0 0.6 9 6 0.6 3 1 1 13 0 0.6 5 0 0.6 4 1 — 0 1.2 1 1.2 3 1 0.4 1.2 0 0.8 2 — 0.2 — — — 4 0.2 0.4 — 0.6 — — — 5 — 0.2 — — — — — — 6 — 0.2 1 0.2

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