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Imagine if you have the remote control that controls all the traffic lights in New York, and you give it to an 8-year old boy, tell him what it does, and send him off to school’that is pretty much what the misuse of hormones would do to our body. One of the main side effects of excess testosterone is decreased size of testes and sperm count and at the same time, an increase in prostate size (exocrine gland of the male reproductive system). The excess level of testosterone can lead to infertility. The reason is that extra testosterone will reduce production of GnRH ‘ gonadotropin releasing hormone, and that will cause the decrease in FSL and LH and that will decrease sperm production and size of testes and number of spermatozoids. In the same time, since the prostate is androgen-responsive tissue (same as muscles), it will be enlarged when there is an increase in androgen hormones. It is important to say that, although we said that muscles are androgen-responsive tissue, they will not grow with only increasing levels of testosterone, but with stimulation like exercises. Muscle hypertrophy is stimulated by stress when muscles are overloaded and »think» they will tear. Only in that case, muscles will start the process of growing ‘ hypertrophy, by increasing protein synthesis (a building block for proteins). Here is the main role of testosterone ‘ increasing protein synthesis (and potentially blocking hormones responsible for muscle ‘ protein degradation, mentioned above). As we mentioned before, exercises will stimulate increase of testosterone levels, but after puberty, when muscle mass will be bigger in males than females, after that growth of muscle mass, adding more testosterone without stimulating muscles, will not increase muscle mass ‘ there will be no muscle hypertrophy. Anabolic steroids, or predominantly testosterone, are often used, or to be precise, abused in sport. The image that most people would have when anabolic steroids are mentioned is bodybuilding. Bodybuilding is an extreme example of muscle growth. The use of steroids and bodybuilding had the same explosion of popularity in the 20 th century. And it is no secret that professional bodybuilders use them in present day. But the story of steroid abuse goes far beyond bodybuilding, almost every sport has some pages of its history written in words on steroids. After the evolution of the synthetic production of steroids, during the cold war when the eastern and western block couldn’t wait to fight the opponent without actually shooting them, and couldn’t wait to prove that they come from a better side of the world, the steroids were passed along the gyms as Tic-Tacs. It was done under doctors’ supervision, but not with doctors’ objections. Only later when negative effects became so apparent, the medicine had to stop the worldwide steroid frat party. But the steroids didn’t vanish. Unlike some other supplements such as human growth hormone, when it comes to steroids, they do increase muscle mass when used in combination with heavy exercising. There is no doubt about that. So the market for them will be ever present, tamoxifen-teva 10 mg antiestrogens nolvadex. Whenever the anonymous surveys are done among young athletes, it is always surprising how many of them say they would risk their health and their sports career, if that would give them the ability to be champions. So steroids became improved, with better production, all for use for medicinal purposes, but a lot of it ends up on the black market.
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