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Good levels of endogenous oestrogen (as estimated from vaginal smears, endometrial biopsy, assay of urinary oestrogen, or endometrial bleeding in response to progesterone) provide a favourable prognosis for ovulatory response induced by Clomid 50 mg Tablets. A low level of oestrogen, although clinically less favourable, does not preclude successful outcome of therapy. Clomid 50 mg Tablets therapy is ineffective in patients with primary pituitary or primary ovarian failure. Clomid 50 mg Tablets therapy cannot be expected to substitute for specific treatment of other causes of ovulatory failure, such as thyroid or adrenal disorders. For hyperprolactinaemia there is other preferred specific treatment. Clomid 50 mg Tablets is not first line treatment for low weight related amenorrhoea, with infertility, and has no value if a high FSH blood level is observed following an early menopause. 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