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Our review included these studies and compared the outcomes between patients with acute exacerbations of ARDS and those with chronic exacerbations. [21,22] As we have already outlined, when ENS evaluation is performed, it is important to do full evaluation of the eicosanoid system and to recognize that there may be an additional role of the eicosanoid system in the regulation of asthma symptoms. [11–13,23] Studies have demonstrated that in subjects with asthma they can be detected in a number of different ways such as using the respiratory function test, nasal measurements, or respiratory acidity. [23–25] Thus, the ability of steroids to treat respiratory symptoms in patients with acute asthma is more consistent with the need for monitoring rather than a direct comparison of steroids with ENS. [21–23] Several recent randomized controlled trials have shown the efficacy of steroids in the management of severe acute respiratory distress syndrome (ARDS), .
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