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Pharma tren e 200, equipoise chapter 65
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Steroids are injected into large muscle groups to provide a slow release into the blood as the steroids gradually release from the oil in the muscle into the bloodstream. This is why the proper injection into the muscle avoiding veins, arteries and nerves is very important. Injection of steroids avoid metabolic degradation by first pass metabolism in the liver which allows the steroids access to the sites where they work throughout the body. This is not the case with steroids taken orally. Steroids taken by mouth must first pass through the liver where significant metabolism takes place. To avoid this extensive metabolism, steroids available today for oral administration have a modification to their structure. This modification introduces a molecular protector into the structure of the steroid which protects the steroid. This modification has a downside in that they become toxic to the liver and can have very serious effects on the liver. 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