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You may want to read other sites on steroid use, including the official site of the International Association for Research in Endocrinology and Diabetes (IARO), a member of the IAA.
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After 2 days after the end of the use of the anabolic, it is necessary to carry out after a course of therapy with Clomid (Tamoxifen is less preferable) within 14 days. For this purpose, the dose of the anabolic must be changed and an additional treatment regimen must be begun (see chapter on Clomid) as described in section 5.5.1.4.5. If Clomid is used for more than 14 days during the year, and for more than 20 years after the end of the prior 3 years, therapy under this section must still be undertaken.
5.5.3.6. The use of aromatase inhibitors is recommended for persons with type 2 diabetes in the prevention of prostate tumours. Prostate cancer is the greatest cause of cancer-related death in men with diabetes in the USA (American Diabetes Association, 2005).
5.5.3.7. Other potential effects of aromatase inhibitors included in PDE3 inhibitors or in the post cycle therapy of PDE4 inhibitors are not included in this section. They include the effect of aromatase inhibitors on sperm motility and its effect on serum lipid and glucose metabolism. Further information on aromatase inhibitors can be found in section 10 of the Pharmacovigilance Committee’s report on the safety and efficacy of PDE4 inhibitors for the prevention, treatment of osteoporosis in women (United Kingdom) (Department of Health, 2005), and in PDE4 inhibitors and the post cycle treatment for cancer in men (UK) (UK Department of Health, 2000). PDE1 inhibitors, in particular, are a risk when used as postcycle therapy for cancer.
5.5.4 Administration of aromatase inhibitors and PDE4 inhibitors for the prevention of cancer
5.5.4.1 The administration of an aromatase inhibitor may be performed at the same time as administration of a PDE4 inhibitor for the purpose of achieving a pharmacokinetic balance (see section 3.2).
5.5.4.2 The PDE4 inhibitors are also administered at the same time as administration of an aromatase inhibitor for the purpose of achieving a pharmacokinetic balance. When the choice of an aromatase inhibitor is critical, it will usually be recommended to first decide of a PDE3 inhibitor. The main effect of PDE3 inhibitors is inhibition of DNA synthesis (Bryant et al., 2006). The main effect of PDE4 inhibitors is inhibition of DNA demethylation (Behnke, 1986), which may promote malignant transformation. This may provide an advantage when tumours are progressing.
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