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Testosterone that is un-esterified holds a very short half-life, making its use very inconvenient and impractical (Testosterone suspension is one such Testosterone product that consists of pure un-esterified Testosterone, and does not have an ester bonded to its structure). The Enanthate ester expands Testosterone’s half-life to that of 10 days, and blood plasma levels of the hormone remain elevated for a total period of approximately 2 ‘ 3 weeks. Testosterone itself is considered the most natural and safest anabolic steroid any individual can use, and it is easily the most versatile and flexible anabolic steroid in terms of how it can be utilized in cycles and for different purposes and goals. The Enanthate variant of Testosterone had first been described in the early 1950s when it had landed on the market and experienced increasingly extensive use shortly thereafter. This was the very first injectable Testosterone ester preparation that provided slower release rates. Prior to the development of Testosterone Enanthate, the most widely utilized forms were either un-esterified Testosterone (Testosterone suspension) or the faster acting Testosterone Propionate, which holds a half-life of approximately 4. As such, Testosterone Enanthate promptly replaced Testosterone Propionate as the Testosterone of choice by the medical establishment in the West, as well as athletes and bodybuilders utilizing it for performance and physique enhancement. In the United States, Delatestryl manufactured by Squibb was the very first Testosterone Enanthate product to be marketed, and it is still manufactured and marketed today only under different pharmaceutical manufacturers that have purchased the rights to market that name brand. Most recently 2005, for example, Indevus was the latest pharmaceutical company to manufacture and market the drug. Internationally (outside of North America, mostly) the brand name for Testosterone Enanthate is known as Testoviron , which unlike Delatestryl, has been manufactured by Schering ever since its original inception well over 50 years ago. Ultimately it is the Testoviron brand name that is the most popular and widely utilized Testosterone Enanthate product in the world, max-pro 100 mg injectable steroids $55.00 masteron. Within the medical realm, Testosterone Enanthate is almost exclusively used for the purpose of treating hypogonadism and andropause (two conditions in which adult males produce inadequate levels Testosterone endogenously). In some lesser cases it is also used as a treatment for delayed puberty male teenagers and for pubertal stimulation. More rare treatments that Testosterone Enanthate is used in include the breast cancer treatment in females. Testosterone Enanthate has also been studied thoroughly in its proposed use as a male birth control treatment. In such cases, it has been determined that a weekly dosage of 200mg had effectively reduced the production of sperm in the majority of men, although 3 months of consistent use was required before significant changes in sperm production and motility were seen. This suppression of spermatogenesis was shown to remain for as long as Testosterone Enanthate was administered, and slowly returned to normal following termination of use. It is highly unlikely however, that Testosterone Enanthate will ever be released and marketed as such due to the immense amount of irrational stigma and hysteria associated with anabolic steroid use in the current Western social climate, which is very unfortunate. Various nations and cultures in Eastern Europe and in the far East, however, have displayed a much more accepting attitude towards its use than in the West. CHEMICAL CHARACTERISTICS OF TESTOSTERONE ENANTHATE. As previously mentioned, Testosterone Enanthate is simply Testosterone with the Enanthate ester bound to the Testosterone chemical structure. Specifically ‘Enanthate’ is Enanthoic acid, but once bound to Testosterone it is properly referred to in chemistry as an ester bond (or ester linkage). Enanthoic acid is bonded to the 17-beta hydroxyl group on the Testosterone structure. Esterified anabolic steroids are more fat soluble, and release slowly from the injection site ‘ however, this is not the main reason as to why esters extend the release rate of the anabolic steroid. The primary reason for the augmentation of its half-life and release rate is because once Testosterone Enanthate enters the bloodstream, enzymes work to break the bond between the ester and the hormone, which takes a varying amount of time.
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Comments : -The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose. BUCCAL : -Mucoadhesive Oral Patch: Apply a 30 mg patch to the gum region twice a day; morning and evening (about 12 hours apart). TOPICAL : -Transdermal Film: 2 to 6 mg applied to the back, abdomen, upper arm, or upper thigh once a day, preferably at night. Consult the manufacturer product information for specific dosage and additional instructions of use, max-pro 100 mg injectable steroids $55.00 masteron. Consult the manufacturer product information for specific dosage and additional instructions of use. Comments: Prior to initiating therapy with this drug, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days, and that these serum testosterone concentrations are below the normal range. Uses : -Primary hypogonadism (congenital or acquired): Testicular failure due to conditions such as cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter Syndrome, chemotherapy, or toxic damage from alcohol or heavy metals. These men usually have low serum testosterone concentrations and gonadotropins (FSH, LH) above the normal range. These men have low testosterone serum concentrations but have gonadotropins in the normal or low range. Usual Adult Dose for Breast Cancer-Palliative. Testosterone Enanthate : -200 to 400 mg IM injection every 2 to 4 weeks. Comments : -Androgen therapy can accelerate the disease. Close monitoring is recommended. Uses : -This drug may be used secondarily in women with advancing inoperable metastatic (skeletal) mammary cancer who are one to five years postmenopausal. Usual Pediatric Dose for Delayed Puberty — Male. IM INJECTION : -Testosterone Enanthate: 50 to 200 mg every 2 to 4 weeks for 4 to 6 months. IMPLANT : -2 pellets (each pellet contain 75 mg of testosterone) implanted subcutaneously every 3 to 6 months -Duration of therapy: 4 to 6 months. Comments : -The chronological and skeletal ages should be taken into consideration when determining the initial dose and when adjusting the dose. Use: To stimulate puberty in selected males with clearly delayed puberty. Testosterone Cypionate IM injection: Contraindicated in renal disease. Testosterone Cypionate IM injection: Contraindicated in liver disease. The doses of this drug should be adjusted according to the patient’s response and the appearance of adverse reactions. IMPLANTS : The number of pellets to be implanted depends upon the minimal daily requirements of testosterone propionate determined by a gradual reduction of the amount administered parenterally. The usual dosage is as follows: -Implant two 75 mg pellets for each 25 mg testosterone propionate required weekly. TOPICAL : -To ensure proper dosing, serum testosterone concentrations should be measured after initiation of therapy to ensure that the desired concentrations (300 ng/dL-1050 ng/dL) are achieved. undefined
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