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Diagnosed or suspected carcinoma of the male breast or prostate. Women who are pregnant or may become pregnant because of possible masculinization of the fetus. When administered to pregnant women, androgens cause virilization of the external genitalia of the female fetus. This virilization includes clitoromegaly, abnormal vaginal development, and fusion of genital folds to form a scrotal-like structure. Patients with a history of hypersensitivity to Test-Prop or any of its components. Patients with serious renal, cardiac, or hepatic dysfunction. In breast cancer patients, androgen therapy may cause hypercalcemia through stimulated osteolysis. Frequent monitoring of urine and serum calcium is indicated in such patients. If hypercalcemia presents, the androgen should be discontinued. Prolonged usage of high doses of androgens has been associated with peliosis hepatis, hepatic neoplasms, and hepatocellular carcinoma as well as azoospermia, oligospermia, and reduced ejaculatory volume. If liver function tests become abnormal or the patient presents with cholestatic hepatitis with jaundice, androgen therapy should be discontinued pending determination of the etiology. Edema due to sodium and water retention may be a serious complication in patients with pre-existing cardiac, renal, or hepatic disease, migraines, epilepsy, and other conditions. Edema may be increased in patients on concurrent adrenal cortical steroid or ACTH therapy. Liver cell tumors have also been reported, most often benign and androgen-dependent, although fatal malignant tumors have also been reported. Termination of the drug generally results in regression or the cessation of tumor progression. Geriatric patients receiving androgen therapy may be at increased risk for prostate hypertrophy and prostatic carcinoma. Virilization of female patients may occur. If signs of virilization present during treatment of breast carcinoma, androgen therapy should be discontinued. PRECAUTIONS: Any nausea, vomiting, changes in skin color or ankle swelling should be monitored by a qualified physician, particularly in patients with a history of severe heart, liver, and kidney disease. Androgen therapy patients receiving concurrent warfarin treatment may present with unexpected increases in the INR and/or pro-thrombin time (PT). When administered to these patients, the dosing of warfarin may need to be reduced significantly to maintain the desired INR level and reduce the risk of serious bleeding. Because androgens may alter serum cholesterol concentration, caution should be used when administering these drugs to patients with a history of myocardial infarction or coronary artery disease. Androgens may reduce clotting factors II, V, VII, and X, and may increase pro-thrombin time (PT), max-one 10 mg oral steroids dianabol. Patients should be instructed to report any use of warfarin and any irregular bleeding. For Women: Women on androgen therapy should be observed for signs of virilization which may include the deepening of the voice, hirsutism, or clitoromegaly.
Women with metastatic breast carcinoma must be followed closely because androgen therapy has been reported in rare instances to accelerate the disease, max-one 10 mg oral steroids dianabol.
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