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Side effects of steroid tablets can include: indigestion or heartburn increased appetite, which could lead to weight gain difficulty sleeping changes in mood and behaviour, such as feeling irritable or anxious an increased risk of infections ‘ especially chickenpox, shingles and measles high blood sugar or diabetes weakening of the bones (osteoporosis) high blood pressure Cushing’s syndrome ‘ which can cause symptoms such as thin skin that bruises easily, a build-up of fat on the neck and shoulders and a red, puffy, rounded face eye conditions, such as glaucoma and cataracts mental health problems, such as depression or suicidal thoughts; get an urgent GP appointment or call 111 if this happens. Most side effects will pass once treatment stops. Tell your doctor if they bother you. You can report any suspected side effect to the UK Yellow Card safety scheme. Coping with side effects of steroid tablets. The following tips may help reduce the side effects of steroid tablets: take your tablets in the morning with breakfast (although some specially coated tablets can be taken without food) ‘ this may help prevent indigestion, heartburn and sleeping difficulties eat a healthy, balanced diet and exercise regularly ‘ this may help prevent weight gain and osteoporosis avoid close contact with people who are ill; especially people who have measles, chickenpox or shingles ‘ get medical advice as soon as possible if you think you may have been exposed to someone with an infection ensure your vaccines are up-to-date ‘ but do not have any «live» vaccines, such as the shingles vaccine. Your doctor may reduce your dose or suggest taking your tablets less often (for example, every other day) if you’re having side effects. They may also sometimes recommend other medicines to take alongside steroids to protect you from some of the side effects, such as medicines to help prevent indigestion or heartburn, or medicines that help strengthen the bones. You may be given a special steroid treatment card that explains how you can reduce the risk of side effects. Taking steroid tablets with other medicines, food or alcohol. Some medicines interfere with the way steroid tablets work. Tell your doctor if you take any other medicines, including herbal remedies and supplements, before starting steroid tablets. If you’re already taking steroid tablets, ask your doctor or a pharmacist for advice before taking any other medicines, remedies or supplements. You can usually drink alcohol while taking steroid tablets, but do not drink too much as this may irritate your stomach. You can also eat most foods while taking steroid tablets. 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