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The steroid users also showed evidence of impaired diastolic function, which is the ability of the left ventricle to relax and fill with blood following contractionof the heart. In non-users, this is a major risk factor for heart and lung disease since it reduces the capacity to expel excess carbon dioxide (hemoglobin), which is an important regulator of blood pressure and heart rate, and for maintaining normal blood sugar levels.

The research team, led by Prof. Jürgen Wegner of the Department of Applied Physiology at the University of Bonn, the Max Planck Institute for Marine and Coastal Research in Hamburg, Germany, analysed the metabolites of steroid users who received a blood test in a lab from July and September 2011. They compared their metabolomes with those of healthy volunteers who took the same test at a later date and were not using any substances.

«We compared the profiles in the two groups to identify those people who have elevated beta-DHEA levels,» explained Dr. Wegner. «The presence of elevated DHEA indicates that someone is using a drug which raises the concentrations of testosterone, DHEA and androstenedione, or androstanediol.»

The levels increased in the steroid users from three weeks before to a year after they started using the drug. By 12 months later, the metabolites of users had increased in levels in all groups, but increased by a much higher magnitude than that observed to date for healthy volunteers.

«We suspect that the higher levels of androstanediol in the users must be responsible,» said Prof. Wegner. «As it is not a common source of estrogen, a similar dose level must be required to raise DHEA levels in the blood to such a level that it can no longer function as an endocrine androgen.»

In conclusion, the team suggests that the elevated DHEA levels seen in the steroid users can be explained more by an increased body weight due to physical inactivity, which is a common theme among steroid users and is especially common among females using steroids.

DHEA is an androgen which stimulates bone, muscle, and the nervous system, among other functions which are needed for the preservation of sexual attractiveness. It is currently used as a hormone in the treatment of erectile dysfunction. DHEA regulates energy supply and is essential for sexual function. It also decreases the risk of cardiovascular diseases and high blood pressure and reduces the risk of skin cancer in men.

Source: JUJ

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