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Fat solubility: Anabolic steroids by nature are lipids (fats), though they are not the traditional chemical characteristic of a hydrocarbon chain. Many of them exist as compounds, containing many molecular species, and there are many examples of steroids that are not lipids but are also lipophilic.
For steroid metabolism, one needs to understand that there exist many substances that are not steroids in nature, but are known to act as steroids. There are also many substances that act as steroids in nature, however, some of those substances have not been known to be hormones or anti-androgens. So for each substance that is known to act as an anti-androgen or anabolic steroid, there is a class of substances that are known to act as hormones or steroidal agents (that is, steroids that have a hormone effect via the actions of estrogen, progesterone, testosterone or androgen receptors). This is known as the steroidal/steroidal triad. For example, among the known compounds known to act as anti-androgens, are the synthetic analogs of testosterone and dihydrotestosterone.
In the case of drugs that are known to affect bone, that is steroids, an important question to address is, if the effect is via their effects on estrogen (or progesterone?) is it also an anti-osteodermic agent? Or, if this effect is via their effects on testosterone? Or, if they affect both hormones equally, can it be an anti-metabolic agent? Or, if the effect is via their effects on sex hormones – estrogen and progesterone? There is a lot to cover with steroids.
Another important question is – can these drugs be abused? Many drugs are abused, many are prescribed by doctors, and those that are prescribed are usually those that have the effects that they are prescribed for. That’s one of the things that we would need to understand – it is very easy to abuse drugs once they are prescribed – for example, if you are prescribed a steroid and don’t take it consistently you have a high risk for abuse.
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Some of the most important drugs of abuse that men misuse are those which are known as anabolic steroids:
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