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The first therapeutic use of steroids occurred in the 18th century when English physician William Withering used digitalis, a compound extracted from the leaves of the common foxglove ( Digitalis purpurea ), to treat edema. Studies of steroids commenced in the early 19th century with investigations of the unsaponifiable (i. This early work, with which many of the noted chemists of the time were associated, led to the isolation of cholesterol and some bile acids in reasonable purity and established some significant features of their chemistry. Insight into the complex polycyclic steroid structure, however, came only after the beginning of the 20th century, following the consolidation of chemical theory and the development of chemical techniques by which such molecules could be broken down step by step. 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