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CNS: Changes in libido, headache, habituation, excitation, generalized paresthesia, insomnia, anxiety and depression. Hematological: Suppression of clotting factors II, V, VII, and X. Bleeding on concomitant anticoagulant therapy. Larynx: Deepening of the voice in females. Fluids and Electrolytes: Retention of electrolytes including sodium, potassium, chlorine, water, calcium, and inorganic phosphates. Hair: Hirsutism and male pattern baldness (androgenetic alopecia) Metabolic: Increased serum cholesterol. Skin: Acne vulgaris, flushing of the skin. Skeletal: Premature closure of epiphyses in children. Other: Rarely, anaphylactoid reactions; inflammation or pain at the injection site. In males: Excessive frequency, duration, and persistence of penile erections. Gynecomastia, Priapism, Inhibition of gonadotrophin secretion, and Oligospermia at high doses. In females: Virilization including clitoral enlargement, menstrual irregularities, amenorrhea, inhibition of gonadotrophin secretion, and deepening of the voice. In pregnant women, virilization of external genitalia of the female fetus. DOSAGE AND ADMINISTRATION: Male Androgen Replacement Therapy: Generally 25 to 50 mg injected intramuscularly (IM) 2 to 3 times per week. Titrate to desired serum levels. Males with Delayed Puberty: Various dosage regimens have been used; some call for lower dosages initially with gradual increases as puberty progresses, with or without a change in maintenance levels. Other regimens call for higher dosages to induce pubertal changes and lower dosages for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose. Dosage is generally within the lower ranges and only for a limited duration, for example, 4 to 6 months. X-rays should be taken at appropriate intervals to determine the amount of bone maturation and skeletal development (see INDICATIONS and WARNINGS). Palliation of Mammary Cancer in Women: Generally a dosage of 50 to 100 mg is administered intramuscularly (IM) 3 times per week. Some physicians prefer short acting testosterone esters for treatment of breast carcinoma during the initiation of therapy for ease of titration and to better assess patient tolerance of the medication. Women with metastatic breast carcinoma must be followed closely because androgen therapy has been reported in rare instances to accelerate the disease. Postpartum Breast Engorgement: Generally 25 to 50 mg administered intramuscularly (IM) for 3 to 4 days beginning therapy at the time of delivery, buy boldenone 300 mg injectable steroids $60.00 equipoise, eq. PRESENTATION: 100 mg/ml, 10 ml multiple dose vials.
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