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The study proven that it offered pretty significant increases in liver enzymes (transaminases AST and ALT) only in the patients that were using 100 mg as they didn’t really got big chances for the patients using 50 mg. There was also a second study done where people were using 50 mg daily to 30 patients for around one year and there were even some patients that took it for longer than that which has proved there are increases in the yglutamyltransferase (GGT) in 17% of patients, pretty significant increases in the bilirubin of 10%, andserum albumin increased in 20%. There’s also a patient which has developed a liver tumor that could have been peliosis hepatitis, that’s a life threatening adverse even that is being characterized by blood filled cysts in the liver. 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