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Anavar is already a derivative of dihydrotestosterone, meaning there is no conversion to DHT via the 5-alpha reductase enzyme, as is the case with decarboxylation to testosterone by dihydrotestosterone. Aromatase expression is strongly related to the extent of fat storage, and it has been found that high levels of Aromatase are associated with fat retention. High levels of Aromatase indicate that muscle tissue is over- stores of testosterone.
Aromatase expression is also higher in postmenopausal women (although not in younger men since they are not able to produce enough Aromatase to support their tissue).
Aromatase expression is also higher in women who exercise regularly, though this is associated with high levels of exercise-induced estrogen in the blood.
One particular protein known as GAPDH (glycoprotein A) is also produced, which promotes fat storage. This is associated with a relatively higher Aromatase expression, as well as increased Aromatase levels. Additionally, a higher level of glycine (a nitrogen-linked amino acid) may induce Aromatase expression.
The aforementioned protein glycine has been found to increase the Aromatase expression in skeletal muscle but this is thought to be somewhat related to hypertrophy of muscle tissue and not Aromatase. In humans, GAPDH also increases Aromatase expression and the levels of dihydrotestosterone that occur in response to exercise, although not as efficiently as glycine.
Interestingly, the activity of dihydrotestosterone (4-hydroxy-DHT) is increased after ingestion of 5mg/kg GDF11; this is known to induce fat storage and may underlie the anti-obese effects of GDF11 (at least in rats). This was later confirmed via animal studies with mice given 4-Hydroxy-DHT, which showed an increase in body mass by 22.8% after four weeks.
Finally, the study of Kishibe et al. noted increased aromatase activity after ingestion of 5mL of 5-hydroxytestosterone, which was not attenuated when they injected 7% fat into the muscle (but not body fat) of the rats they tested; this may suggest that the fat can be increased in response to insulin.
These effects seem to be induced by the action of 5-hydroxytestosterone itself in muscle tissue. The
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Anabolic steroids are synthetic (man-made) drugs that are similar to the male hormone testosterone. Their proper name is anabolic-androgenic steroids (aas). — thinking about using anabolic steroids to build muscles or improve your athletic performance? think again. Misusing them is not legal or. Abstract: anabolic steroids are composed of testosterone and other substances related to testosterone that promote growth of skeletal muscle, increase. What are they? there are two types of steroids — corticosteroids and anabolic steroids. Corticosteroids include drugs such as prednisone, cortisone, depomedrol
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