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Nu s-au observat interactiuni severe. Medicamentele hipolipemiante, de tipul colestiraminei sau colestipolului, si antiacidele ce contin hidroxid de aluminiu — trisilicat de magneziu pot diminua absorbtia UDCA si, astfel, pot diminua efectul medicamentului. Nu este recomandata administrarea la pacientii. Aceste medicamente cresc secretia de colesterol in bila si scad eficacitatea tratamentului. Contraceptivele orale, estrogenii si dietele. Ursochol poate creste absorbtia ciclosporinei din intestin. De aceea, pacientilor tratati cu ciclosporina trebuie sa li se monitorizeze concentratiile plasmatice de ciclosporina si daca este necesar se vor ajusta dozele de ciclosporina. In cazuri izolate, Ursochol poate reduce absorbtia ciprofloxacinei. Trebuie atentionati sa nu utilizeze acest medicament: pacientii care au colici biliare frecvente, cu infectii grave, modificari ale pancreasului sau afectiuni intestinale care pot afecta circulatia enterohepatica a acizilor biliari (rezectia sau ileostomia, ileita regionala). Deoarece medicamentul contine lactoza, administrarea nu este recomandata la pacientii cu intoleranta. Tratamentul nu se administreaza la copii. A nu se pastra la indemana copiilor. Sarcina si alaptarea: In studiile la animal au fost demonstrate efecte teratogene la o specie; la om, nu exista suficienta. De aceea Ursochol este contraindicat in timpul primului trimestru de sarcina. Inaintea inceperii tratamentului trebuie exclusa existenta unei eventuale sarcini. Femeile de varsta fertila care utilizeaza Ursochol trebuie sa foloseasca o metoda de contraceptie adecvata. Din al doilea trimestru de sarcina, medicul poate indica Ursochol numai daca este absolut necesar, dupa o apreciere adecvata a raportului risc fetal/beneficiu matern al terapiei. Deoarece nu sunt disponibile suficiente informatii privind excretia acidului ursodeoxicolic in laptele matern, Ursochol nu trebuie utilizat in timpul alaptarii. Capacitatea de a conduce vehicule sau de a folosi utilaje. Nu exista dovezi privind efecte ale produsului asupra atentiei si a timpului de reactie ale pacientilor. Doze si mod de administrare. Pentru dizolvarea calculilor biliari cu continut de colesterol, doza este de 300-600 mg pe zi (dupa sau in timpul meselor) coreaspunzator la 2-4 comprimate de Ursochol a 150 mg sau 1-2 comprimate Ursochol a, alphabolin 100 mg injectable steroids $97.00 primobolan, primo. Pentru a mentine conditiile favorabile pentru dizolvarea calculilor biliari existenti, tratamentul trebuie sa dureze cel putin 4-6 luni pana la 12 luni sau mai mult, in functie de dimensiunea calculilor si evolutia sub tratament. Pentru tratamentul de mentinere sunt suficiente doze de 150 mg de 2 ori pe zi sau de 300 mg o data pe zi. In sindroamele dispeptice biliare, doza este de 1 comprimat a 150 mg de 2 ori pe zi.
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