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Although Proviron is considered a very old medication, it still stands the test of time as being known as a compound that has impressive effectiveness as a medicine alongside an impressive history of safety and tolerance among patients. Within the medical establishment, Proviron has been utilized as a medication for the treatment of declining well-being in older males due to declining androgen levels, libido dysfunction in males, and infertility. Its use as a fertility aid is where Proviron was really emphasized in medical literature. This is because while almost all anabolic/androgenic steroids are known to cause temporary infertility, Proviron in normal therapeutic dosages actually barely suppresses endogenous gonadotropins (LH and FSH) when utilized. However, Proviron is poorly misunderstood as a compound that increases LH, which it does not do. Instead, research has demonstrated that Proviron provides the androgenic effects necessary for spermatogenesis in specific areas in the testes. Schering still manufactures Mesterolone under the name of Proviron across the world today. It has been sold under different brand names as well, including Pluriviron (in Germany by Asche), Vistimon (in Germany by Jenepharm), and Restore (in India, by Brown and Burke). What is interesting, however, is that Proviron was never approved for use on the prescription market in the United States. Proviron is a modified derivative of dihydrotestosterone (DHT) via the addition of a methyl group on its first carbon (1-methyl dihydrotestosterone). As previously mentioned, it is an extremely weak anabolic, which is why Proviron is almost always referred to as an androgen (or androgenic steroid). Studies have demonstrated the reason for its weak anabolic effects: it shares with its parent compound (DHT) a similar property ‘ it is rapidly metabolized and broken down into inactive metabolites once it enters into muscle tissue. This has always been the problem with dihydrotestosterone itself ‘ once it enters muscle tissue, the enzyme 3-hydroxysteroid dehydrogenase (where it is in very high concentration in muscle tissue) binds to it, and renders it inactive by converting it into a compound that has no anabolic effects. This is the real reason for Proviron’s weak anabolic effects. There have been false rumors about Proviron’s weak anabolic nature in circulation among bodybuilding communities that Proviron ‘blocks the androgen receptor in muscle tissue’, which is wrong, and this rumor should therefore be put to rest. An added benefit of Proviron is its ability to have a high affinity for SHBG (Sex Hormone Binding Globulin), which is a protein that binds to anabolic steroids in the bloodstream (namely, Testosterone) and renders them completely inactive once bound. The use of Proviron in this case alongside other anabolic steroids may magnify the activity and effects of other anabolic steroids through this pathway, leaving more unbound and free Testosterone to perform its job. A well-known benefit of Proviron is also its ability to act as an anti-estrogen via its activity as an aromatase inhibitor. It should be noted, however, that its activity as an aromatase inhibitor is not regarded as strong as Aromasin, Arimidex, or Letrozole, but it still works and can be used as such, buy gp exemestane 25 mg antiestrogens $34.00 aromasin. Its strength as an aromatase inhibitor can be compared to Arimidex, but slightly lower in terms of strength. Because Proviron is a DHT-derivative, it carries with it no risks at any dosage for estrogenic side effects. In fact, as previously mentioned, Proviron acts as an anti-estrogen via its activity as an aromatase inhibitor in the body. This can result in the mitigation of estrogenic side effects from other compounds via the reduction of total circulating plasma levels of Estrogen. Research has demonstrated that because of this effect of Proviron, it has been utilized medically in the treatment of gynecomastia and breast cancers because of its strong androgenic nature combined with its anti-estrogenic capabilities. Because Proviron is primarily an androgen, it does carry with it the risk of androgenic side effects, and they are more pronounced with higher dosages.
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