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Andarine is designed specifically for the treatment of muscle atrophy, perfectly copes with the suppression of destructive catabolism, and can be used in a more aggressive manner with the potential to enhance mitochondrial dysfunction and oxidative stress. Because of such factors, I am confident that there was no way this study could have been done correctly.
The authors of this paper also mention that they were unsure if this was placebo effect, or if just a placebo effect was present. I think I can speak for the general public when I say that we do have a lot of distrusting of any study being a placebo effect study, because that tends to indicate that the participants were in the placebo group and the treatment group was actually more severe, with a greater level of injury of disease.
It appears that the researchers made a decision early on to look at the muscle wasting, with a focus on the atrophy. But in doing so, they did not look at any other parameters such as exercise duration, diet, or rest. Their focus was solely on how these individuals’ muscles degraded as a result of decreased fitness. As I have mentioned here before, when you’re a professional athlete trying to reach the top of your sport in a sport where there are no set protocols for training, this kind of «skepticism» is very common.
I’d like to conclude this post by quoting this quote from Dr. David Epstein:
«[The lack of follow-up] is a serious omission. It is not an acceptable situation for any medical research to rely on the assumption that a clinical trial will yield all necessary treatment results. That is why we require detailed reports (eg, in the form of a data declaration) and careful justification before a drug is approved for human use. That is why we demand that an independent research protocol is agreed to between the investigators and the sponsor of the trial. The study in this case was a commercial trial, and the sponsor, ABI Research, had absolutely no obligation to report the nature of the experimental protocols or the outcomes to us. They certainly did not share this information with us, nor did they communicate to us any concerns that were specific to this trial. These results should be verified in a full-blown study before any regulatory or medical body takes an interest.»
This quote speaks directly to the researchers’ failure to communicate with me, the patient and the medical community. This is an example of exactly why most of us need to become informed citizens about our medical devices and supplements. That said, if you have any doubts as to whether your product is appropriate for you or even whether it really works, I suggest you do
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